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Chemoenzymatic Synthesis of Stegobinone and Stegobiol

Wednesday, 13 April 2016

Chemoenzymatic Synthesis of Stegobinone and Stegobiol, Components of the Natural Sex Pheromone of the Drugstore Beetle (Stegobium paniceum L.)

Dimitris Kalaitzakis, Ioulia Smonou


eurjocEuropean Journal of Organic Chemistry
Volume 2012, Issue 1, pages 43-46, January 2012
DOI: 10.1002/ejoc.201101319


The work of Dimitris Kalaitzakis and Ioulia Smonou on the chemoenzymatic synthesis of a natural pheromone has been highlighted on the cover picture of the European Journal of Organic Chemistry.

stereoselective

The chemoenzymatic stereoselective synthesis of the two components of the natural sex pheromone of the drugstore beetle was achieved by using ketoreductases as the biocatalysts in the key steps. Optically pure and crystalline Stegobinone was obtained free of its 1′-epimer, which is strongly repellent to  Stegobium paniceum.


http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201101319/full

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