A Versatile Synthesis of Meyers’ Bicyclic Lactams from Furans.

Wednesday, 13 April 2016

(Synthetic Methods)

Dimitris Kalaitzakis, Tamsyn Montagnon, Ioanna Alexopoulou and Georgios Vassilikogiannakis*

Angewandte Chemie (early view)


A Versatile Synthesis of Meyers' Bicyclic Lactams from Furans: Single-Oxygen-Initiated Reaction Cascade.


All in one: Meyers' bicyclic lactams were synthesized in high yield from furans using a new and powerful method that involves a one-pot singlet oxygen-initiated reaction cascade. This method, developed by Vassilikogiannakis' group, has a broad synthetic potential because of the ease of access to a wide range of furans with a variety of substituents.

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